Batsheva de Rothschild Seminar on: Stochasticity and Control in the Dynamics and Diversity of Immune Repertoires

Group Conference

Event date: June 18 - June 23, 2017

Organizers:
    Uri Hershberg (Drexel University)
    Gur Yaari (Bar-Ilan University)
    Nir Friedman (Weizmann Institiute)
    Sol Efroni (Bar-Ilan University)
    Tomer Hertz (Ben Gurion University )

     

    Immuno-biology research is at a turning point. Novel experimental methods make possible high-throughput imaging and molecular measurements at the single cell and single molecule level. Along with the great promise these technologies bring, they also call for new theoretical and computational approaches to catalyze our assimilation of this overwhelming wealth of data. The new data are revolutionizing our picture of the variability and control in biology in general and, in particular, the adaptive immune system. The adaptive immune system provides robust defense against evolving pathogenic threats. Underlying this ability is the dynamics of immune repertoires, which are a fascinating example for the symbiotic relationship between stochasticity and control in a biological system. We will discuss how the adaptive immune system is organized to take advantage of stochastic processes at the genetic, molecular, and cellular levels combined, to generate robust immune responses. This is a cross-disciplinary topic and our goal is to combine perspectives from systems biology, mathematical modeling and experimental immunology into a coherent whole. With the help of world leaders and promising young researchers in immunology we will exchange ideas about stochasticity and control in the adaptive immune system and attempt to put immunology on a new theoretical footing based on the most recent high throughput experimental results.

     

    Confirmed Speakers:

     

     

    Becca AsquithImperial College, London, UK
    Scott BoydStanford, USA
    Felix BredenSimon Fraser University, Canada
    Sarah CobeyUniversity of Chicago, USA
    Irun CohenWeizmann Institute of science, Israel
    Andrew CollinsUniversity of New South Wales, Australia
    Rob de BoerUtrecht University, Netherlands
    Daniel DouekNIAID/VRC, USA
    Deborah Dunn WaltersUniversity of Surrey, UK
    Sol EfroniBar Ilan University, Israel
    Martin FlajnikUniversity of Maryland, USA
    Nir FriedmanWeizmann Institute of science, Israel
    RonaldGartenhausUniversity of Maryland School of Medicine, USA
    Roi GazitBen-Gurion University of the Negev, Israel
    Uri HershbergDrexel, USA
    Tomer HertzBen-Gurion University of the Negev, Israel
    Phil HodgkinWalter and Eliza Hall Institute of Medical Health, Australia
    Tomas HöferDeutsches Krebsforschungszentrum, Heidelberg, Germany
    Tom KeplerBoston University, USA
    Steven KleinsteinYale University School of Medicine, USA
    Marie-Paule LEFRANCUniversity of Montpellier
    Michael LevittStanford, USA
    Yoram LouzounBar Ilan University, Israel
    Ramit MehrBar Ilan University, Israel
    Thierry MoraEcole Normale Supérieure, France
    Yanay OfranBar Ilan University, Israel
    Michal Or GuilHumboldt University, Berlin, Germany
    Andrea PagnaniPolitecnico di Torino – DISAT, Italy
    Leila PerieCurie Institute, France
    Franccisco QuintanaHarvard, USA
    Jamie ScottSimon Fraser University, Canada
    Shai Shen-orrTechnion, Israel
    Eilon ShermanThe Hebrew University of Jerusalem, Israel
    Mark ShlomchikUniversity of Pittsburgh, USA
    Mikhail ShugayInstitute of bioorganic chemistry of the Russian Academy of Sciences
    Johannes TextorRadboud University Medical Center
    Corey WatsonUniversity of Louisville, USA
    Yariv WineTel Aviv University, Israel
    Gur YaariBar Ilan University, Israel